I became an Undergraduate Research Assistant with this project in the spring of 2018 under an ND NASA EPSCoR RID. The research is based on the research of Thomas Heldt whose papers will be referenced later. The point of the research is to use his derived arterial and capillary models, we theoretically can get a more accurate representation of blood pressure and flow through the cardiovascular system. Then this model can be used to periodically model a gradient of moving from the gravity of earth to our body adapting to microgravity in orbit. This will be done through a simulation to reduce time spent.
The simulation software that we are using is called CVSim and based on the model of Thomas Heldt. We are using the 21-compartment program in order to get the most accuracy. We are adding additional equations into the program thereby including a "capillary" compartment located between pre-capillary and post-capillary elements of the cardiovascular system. The model includes osmotic pressure through which the pressure is applied on each side of the capillaries. It also includes a basic lymphatic system model for the return to the lymph nodes via capillaries. This is also based on Thomas Heldt's, "A Computational Model of Hemorrhage and Dehydration Suggests a Pathophysiological Mechanism: Starling-Mediated Protein Trapping."